Endocrine Abstracts

Ghrelin and PYY are gastrointestinal peptides involved in appetite regulation. The cholinergic part of the vagal nerve participate in the regulation of glucose and insulin levels. We aimed to examine the effects of the cholinergic antagonist atropine on ghrelin, PYY, glucose and insulin under basal conditions and after meal ingestion in lean and obese subjects. Eight lean and eight obese subjects received in a randomized, double-blind, placebo controlled crossover study design...

Background: Craniopharyngiomas (CP) are benign brain tumours presenting in childhood treated by tumour resection together with radiotherapy. In about half of the cured patients hypothalamic damage leading to eating disorders and obesity as well as to hypopituitarism, necessitating consequent hormone substitution therapy, is observed. Bariatric surgery is an efficient treatment strategy for morbid obesity. However, so far it is unknown, whether oral hormone substitution is hamp...

Recent case reports describe hyperinsulinemic hypoglycemia after gastric bypass. The aim of this study was the assessment of insulin resistance and insulin secretion in non-diabetic morbidly obese patients before and six months after bariatric surgery.In 8 non-diabetic morbidly obese patients (OB:6f/2 m, age:42±3a, BMI:47.29±2.2 kg/m2) and 6 controls (CON:4f/2 m, age:43±0a, BMI:23.8±0.5 kg/m2) we performed a freq...